Ethanol → HCID 13882134, 화합물

HRID 867384노트

반응식

HRID 867384 반응식
[C:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:6]=[CH:5][C:4]=1[C:15]([O:17]CC)=[O:16])#[N:2].[OH-].[K+].C([OH:24])C>O>[C:15]([C:4]1[CH:5]=[N:6][N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:3]=1[C:1]([NH2:2])=[O:24])([OH:17])=[O:16]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 13772963Ethyl 5-cyano-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

생성물 1

HCID 13882134HCID 13882134, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 2.5 g. portion of ethyl 5-cyano-1-(4-fluorophenyl)-4-pyrazolecarboxylate was combined with 2.6 g. of potassium hydroxide and stirred under reflux in 100 ml. of denatured ethanol for 4 hours. It was then cooled, made acid, diluted with water, and concentrated under vacuum to obtain 2.8 g. of the desired compound, m.p. 232° dec. after recrystallization from acetone. It was identified by elemental analysis.

후처리

  1. temperatureunder reflux in 100 ml
  2. temperatureIt was then cooled
  3. concentrationconcentrated under vacuum
  4. customto obtain 2.8 g
  5. customof the desired compound, m.p. 232° dec. after recrystallization from acetone

출처 및 근거

ORD 기록
ord-da49caf879b34e3faf5b1248613c8a40
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775409

반응 노트

불러오는 중…