Acetyl chloride → HCID 2825757, 화합물

HRID 867427노트

반응식

HRID 867427 반응식
[CH3:1][C:2]1([CH3:16])[S:6][C@@H:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:4][C@H:3]1[C:13]([OH:15])=[O:14].[C:17](Cl)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([N:4]1[C@@H:3]([C:13]([OH:15])=[O:14])[C:2]([CH3:16])([CH3:1])[S:6][C@H:5]1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:19])[CH3:18]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 14548321HCID 14548321, 화합물

생성물 1

HCID 2825757HCID 2825757, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

0.47 g (2 mmoles) of 5,5-dimethyl-2(S)-phenylthiazolidine-4(S)-carboxylic acid is suspended in 5 ml of pyridine while stirring. The temperature of the suspension is adjusted to 5° C. by cooling with ice-water and 0.17 g of acetyl chloride is dropped in. The mixture is stirred for 1 additional hour, then poured in 60 ml of ice-cold 2N sulphuric acid. After several hours, the precipitated product is filtered out, washed with water and dried. The product is dissolved in ethanol and water is added to precipitate the title compound in a yield of 0.38 g (70.3%), m.p.: 216°-217° C., [α]D20 =-109° (c=0.686, methanol).

후처리

  1. customis adjusted to 5° C.
  2. additionis dropped in
  3. stirringThe mixture is stirred for 1 additional hour
  4. waitAfter several hours
  5. filtrationthe precipitated product is filtered out
  6. washwashed with water
  7. customdried
  8. dissolutionThe product is dissolved in ethanol
  9. additionwater is added
  10. customto precipitate the title compound in a yield of 0.38 g (70.3%), m.p.: 216°-217° C., [α]D20 =-109° (c=0.686, methanol)

출처 및 근거

ORD 기록
ord-7c8dccdb8c5a48e9a22679beb704e8de
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775675

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