Piperidine → 1-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one

반응식

[CH3:1][N:2]1[C:14]2[C:5](=[N:6][C:7]3[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)=[CH:11][C:12]=3[CH:13]=2)[NH:4][C:3]1=[O:22].[NH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][N:2]1[C:14]2[C:5](=[N:6][C:7]3[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][C:19]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)=[O:21])=[CH:11][C:12]=3[CH:13]=2)[NH:4][C:3]1=[O:22]

참가 물질

반응물 2

HCID 8082Piperidine

HCID 142809914-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid

생성물 1

HCID 142810121-Methyl-7-(4-oxo-4-piperidin-1-yl-butoxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one

실험 절차

This compound, m.p. 215°-217° C., prepared analogous to Example 15 from 4-[(2,3-dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid and piperidine.

출처 및 근거

ORD 기록: ord-463258efc2a4499cad99712f2527f4ae
출처 데이터셋: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04775674

반응 노트

불러오는 중…