2-Fluoro-4-(trifluoromethyl)pyridine → 2-Azido-5-(trifluoromethyl)pyridine

반응식

[N:1]([C:4]1[CH:9]=[C:8](C(F)(F)F)[CH:7]=[CH:6][N:5]=1)=[N+:2]=[N-:3].FC1C=C([C:21]([F:24])([F:23])[F:22])C=CN=1>>[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:21]([F:24])([F:23])[F:22])=[CH:6][N:5]=1)=[N+:2]=[N-:3]

참가 물질

반응물 2

HCID 111595142-Fluoro-4-(trifluoromethyl)pyridine

HCID 151506942-Azido-4-(trifluoromethyl)pyridine

생성물 1

HCID 151506932-Azido-5-(trifluoromethyl)pyridine

실험 절차

The following were prepared analogously and analyzed by nmr spectroscopy: 2-azido-4-(trifluoromethyl)pyridine, off white crystals (from 2-fluoro-4-(trifluoromethyl)pyridine; and 2-azido-4,6-bis(trifluoromethyl)pyridine, pale yellow oil crystallizing on standing (from 2-chloro-4,6-bis(trifluoromethyl)pyridine.

후처리

customThe following were prepared analogously
customand 2-azido-4,6-bis(trifluoromethyl)pyridine, pale yellow oil crystallizing

출처 및 근거

ORD 기록: ord-6f04ff5df6b64738a0bedaf065594398
출처 데이터셋: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04775762

반응 노트

불러오는 중…