Dichloromethane → (trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acid

HRID 867653노트

반응식

HRID 867653 반응식
C([N+](CCCC)(CCCC)CCCC)CCC.C(OC([NH:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([O-:35])(=[O:34])=[O:33])[C:27]1=[O:36])=O)(C)(C)C.ClCCl>C(O)=O>[NH2:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([OH:35])(=[O:33])=[O:34])[C:27]1=[O:36]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 131714274(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt

생성물 1

HCID 13575528(trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acid수율 34.7%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt (6.75 g) in 40 ml of 98% formic acid is stirred for 3 hours at ambient temperature. Dichloromethane (60 ml) is added and the mixture is refrigerated for about 16 hours. The resulting precipitate is separated by filtration and then dried in vacuo to yield 0.85 g of the title compound, melting point 185° C., dec.

후처리

  1. customThe resulting precipitate is separated by filtration
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-f0bb8e6b1f844640b2388124c3912948
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04775670

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