Ammonia → HCID 19980851, 화합물

HRID 867941노트

반응식

HRID 867941 반응식
[NH3:1].O=[C:3]([CH3:11])[CH2:4][C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]>C(O)C>[NH2:1]/[C:3](/[CH3:11])=[CH:4]\[C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 118544Butanoic acid, 3-oxo-, 2-hydroxyethyl ester

생성물 1

HCID 19980851HCID 19980851, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Anhydrous ammonia gas was bubbled through a solution of 2-hydroxyethyl 3-oxo-butyrate (25 g, 0.17 moles) (ref 5) and ethanol (250 mL) for 20 minutes. This solution was stirred for 16 hours at room temperature. The solvent was removed in vacuo and the resulting oil was chromatographed on silica gel (250 g) using etyl acetate-hexane 60:40 as eluant. The enriched fractions were combined and the solvent removed in vacuo to give the product; H' NMR CDCl3 4.33 (t, 2H) 3.85 (t, 2H) 3.55 (s, 1H) 2.85 (broad singlet, 1H) 2.31 (s, 3H).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe resulting oil was chromatographed on silica gel (250 g)
  3. customthe solvent removed in vacuo
  4. customto give the product

출처 및 근거

ORD 기록
ord-fe2403b9755f4cf5b8c3991761bf7c55
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04777167

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