Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | 6-Amino-1-propyluracil | HCID 104562 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 촉매 | Platinum | HCID 23939 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione | HCID 15931310 | — |
반응 단계
Sodium nitrite (127 kg) was dissolved in water and added to suspension of 6-amino-1-propyl-2,4-(1H,3H)-pyrimidinedione (300 kg) in formic acid (1 400 kg). Pt/C 5 % was added and the reaction mixture was heated to 40°-80° C. The catalyst was filtered off, formic acid was distilled off and ethanol (870 kg) was added. The product was precipitated by cooling and isolated by centrifugation, washed with ethanol/water and used directly in Example 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04777255 |
| 출처 데이터셋 | uspto-grants-1988_10 |
| ORD ID | ord-c989df1d00ac4daeaf6f9d8b1d9d8be3 |
| 출처 메모 | uspto-grants-1988_10 |