Formic Acid → 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

HRID 867945

반응식

HRID 867945 반응식
[N:1]([O-])=O.[Na+].[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[CH:7]=1.[CH:17]([OH:19])=O>O.[Pt]>[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[C:7]=1[NH:1][CH:17]=[O:19]

참가 물질

6

반응물 3

HCID 284Formic AcidHCID 1045626-Amino-1-propyluracilHCID 23668193Sodium Nitrite

생성물 1

HCID 159313106-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 962Water용매

실험 절차

Sodium nitrite (127 kg) was dissolved in water and added to suspension of 6-amino-1-propyl-2,4-(1H,3H)-pyrimidinedione (300 kg) in formic acid (1 400 kg). Pt/C 5 % was added and the reaction mixture was heated to 40°-80° C. The catalyst was filtered off, formic acid was distilled off and ethanol (870 kg) was added. The product was precipitated by cooling and isolated by centrifugation, washed with ethanol/water and used directly in Example 2.

후처리

  1. temperaturethe reaction mixture was heated to 40°-80° C
  2. filtrationThe catalyst was filtered off
  3. distillationformic acid was distilled off
  4. additionethanol (870 kg) was added
  5. customThe product was precipitated
  6. temperatureby cooling
  7. customisolated by centrifugation
  8. washwashed with ethanol/water

출처 및 근거

ORD 기록
ord-c989df1d00ac4daeaf6f9d8b1d9d8be3
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04777255

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