Acetonitrile → 3-[3-(2-Azepan-1-yl-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

HRID 8681노트

반응식

Br[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[O:13][N:12]=2)[CH:8]=[CH:9][CH:10]=1.C(=O)([O-])[O-].[K+].[K+].[C:25](#[N:27])[CH3:26]>>[N:27]1([CH2:2][CH2:3][O:4][C:5]2[CH:6]=[C:7]([C:11]3[C:15]4[S:16][CH:17]=[CH:18][C:14]=4[O:13][N:12]=3)[CH:8]=[CH:9][CH:10]=2)[CH2:9][CH2:10][CH2:5][CH2:6][CH2:26][CH2:25]1

참가 물질

반응물 3

HCID 6342Acetonitrile

HCID 11430Potassium Carbonate

HCID 219835823-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

생성물 1

HCID 97981413-[3-(2-Azepan-1-yl-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

실험 절차

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, hexamethyleneimine and acetonitrile essentially as described above in example 40. Purity by LC/MS (APCI)=99%, [M+H]+=343.

출처 및 근거

ORD 기록: ord-6c2c563a30e04c3f95fd9e00eaaedf6d
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091199B1

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