Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-benzylazetidine-3,3-dicarboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | [1-Benzyl-3-(hydroxymethyl)azetidin-3-YL]methanol | HCID 20164320 | — |
| 촉매 | Nickel Sulfate | HCID 24586 | — |
| 생성물 | 1-benzylazetidine-3,3-dicarboxylic Acid | HCID 11310885 | — |
반응 단계
Bromine (10.6 g) was slowly added at 20° C. over 8 hours to a mixture of N-benzyl-3,3-bis(hydroxymethyl)azetidine (2.1 g) in water (50 ml) containing sodium hydroxide (9.3 g) and nickel chloride 6.0 aq. (1.5 g). After stirring overnight, the green precipitate of nickel hydroxide was filtered off, and the filtrate evaporated to dryness. The residue was boiled in ethanol, and the insoluble material (desired product as sodium salt and sodium bromide) separated and worked up to yield the N-benzyl-azetidine-3,3-dicarboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04778577 |
| 출처 데이터셋 | uspto-grants-1988_10 |
| ORD ID | ord-838be3ff0e684522a9c780bbcef962f4 |
| 출처 메모 | uspto-grants-1988_10 |