Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochlorothiazide → 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochlorothiazide | HCID 3639 | — |
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Benzylbromoacetate | HCID 21881508 | — |
| 생성물 | 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine | HCID 14280971 | — |
반응 단계
Treat 6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine with Cs2CO3 and substitute 1,2-dibromoethane for benzylbromoacetate in the procedure of Example 7, step A to obtain 2-(2-bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04778795 |
| 출처 데이터셋 | uspto-grants-1988_10 |
| ORD ID | ord-6b9669262562417cac6d976e2a44bae5 |
| 출처 메모 | uspto-grants-1988_10 |