Pyridine → N-[[[1-(6-Fluoro-2-naphthalenylmethyl)-4-piperidinyl]amino]carbonyl]-6-quinoline carboxamide

HRID 868214

반응식

HRID 868214 반응식
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](Cl)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[F:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([NH:32][C:33]([NH2:35])=[O:34])[CH2:28][CH2:27]1)[CH:19]=[CH:18]2.N1C=CC=CC=1>ClCCCl>[F:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH2:25][N:26]1[CH2:27][CH2:28][CH:29]([NH:32][C:33]([NH:35][C:11]([C:7]3[CH:6]=[C:5]4[C:10](=[CH:9][CH:8]=3)[N:1]=[CH:2][CH:3]=[CH:4]4)=[O:12])=[O:34])[CH2:30][CH2:31]1)[CH:19]=[CH:18]2

참가 물질

5

반응물 3

HCID 1049PyridineHCID 12391963Quinoline-6-carbonyl chlorideHCID 21288076HCID 21288076, 화합물

생성물 1

HCID 13853618N-[[[1-(6-Fluoro-2-naphthalenylmethyl)-4-piperidinyl]amino]carbonyl]-6-quinoline carboxamide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

A mixture of 6-quinolinoyl chloride (4.77 g, 22 mmol), N-[[(6-fluoro-2-naphthalenyl)methyl]-4-piperidinyl]urea (6.02 g, 20 mmol), dry pyridine (2.5 ml) and 1,2-dichloroethane (30 ml) is stirred at reflux for 18 hours. The solution is then cooled, washed with aqueous sodium carbonate solution, dried and evaporated. The residue is crystallised from ethanol to give the title compound, mp 200°-201° C. (softens, maleate salt).

후처리

  1. temperatureat reflux for 18 hours
  2. temperatureThe solution is then cooled
  3. washwashed with aqueous sodium carbonate solution
  4. customdried
  5. customevaporated
  6. customThe residue is crystallised from ethanol

출처 및 근거

ORD 기록
ord-fe4ffe43b4e3413780803c628c8a457f
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04778802

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