Malonic Acid → 3-(4-Phenyl-3-pyridyl)acrylic acid
반응식
[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][C:8]=2[CH:13]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=O)[CH2:16][C:17]([OH:19])=[O:18].N1CCCCC1.N1C=CC=CC=1>C(OCC)C>[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][C:8]=2[CH:13]=[CH:16][C:17]([OH:19])=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1참가 물질
6
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 4.3 g of 4-phenyl-3-pyridinecarbaldehyde [cf. Heterocycles, 14, 813 (1980)], 2.5 g of malonic acid, 0.5 ml of piperidine, and 6 ml of pyridine is stirred at 100° C. for 2 hours. After cooling, 50 ml of diethyl ether is added, and the resulting precipitate is collected. The obtained solid is washed with water and dried to give 3.4 g of the title compound.
후처리
- temperatureAfter cooling
- customthe resulting precipitate is collected
- washThe obtained solid is washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-f1e2ee7d3787457791a3e82c719d748a
- 출처 데이터셋
- uspto-grants-1988_10
- 특허 번호
- US04778796
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