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2-(Benzyloxy)-3-(octadecyloxy)propyl 10-trimethylammoniodecyl phosphate → 2-(Hydroxy)-3-(octadecyloxy)propyl 10-trimethylammoniodecyl phosphate

HRID 868441
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HRID 868441 반응식
[P:1]([O-:49])([O:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][N+:45]([CH3:48])([CH3:47])[CH3:46])([O:3][CH2:4][CH:5]([O:26]CC1C=CC=CC=1)[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:2]>C(O)C.C(O)(=O)C.[Pd]>[P:1]([O-:49])([O:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][N+:45]([CH3:48])([CH3:47])[CH3:46])([O:3][CH2:4][CH:5]([OH:26])[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 142809452-(Benzyloxy)-3-(octadecyloxy)propyl 10-trimethylammoniodecyl phosphate

생성물 1

HCID 141280742-(Hydroxy)-3-(octadecyloxy)propyl 10-trimethylammoniodecyl phosphate수율 88.8%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 176Acetic Acid용매HCID 702Ethanol용매

실험 절차

1.31 g (1.8 mmole) of the compound of Example 4 was dissolved in a mixture of 100 ml of ethanol and 50 ml of 70% acetic acid. Then, 0.6 g of 10% Pd-C was added thereto and catalytic reduction was carried out at room temperature. 19 hours later, the reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure. The residue was solidified by acetone to give 994 mg (yield: 87.2%) of the desired product.

후처리

  1. customwas carried out at room temperature
  2. filtration19 hours later, the reaction mixture was filtered
  3. concentrationthe filtrate was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-429e0ae8c2384c17acc91e83613e0a50
출처 데이터셋
uspto-grants-1988_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04778912

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