Aniline → HCID 178420476, 화합물
반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1C=CC=CC=1>[NH:11]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1참가 물질
4
반응 조건
- 온도
- 130 °C
실험 절차
To 7-chloro-3H-imidazo(4,5-b)pyridine (16 g, 97 mmol) was added aniline (200 mL, 2.1 mol). The resulting mixture was heated under a nitrogen atmosphere at 130° C. for 24 hours. Benzene was added to the cooled mixture and the precipitate was filtered. The solid was dissolved in water and 1N NaOH was added to give a pH reading of 9. The precipitate was filtered and recrystallized from EtOH (decolorized by charcoal) to give 7.2 g (35%) of the 7-anilino-3H-imidazo[4,5-b]pyridine, m.p. 251°-252° C.
후처리
- filtrationthe precipitate was filtered
- dissolutionThe solid was dissolved in water
- addition1N NaOH was added
- customto give a pH reading of 9
- filtrationThe precipitate was filtered
- customrecrystallized from EtOH (decolorized by charcoal)
출처 및 근거
- ORD 기록
- ord-59b59e1f99e742fbb2f87a42ca359448
- 출처 데이터셋
- uspto-grants-1988_10
- 특허 번호
- US04780452
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