Potassium Carbonate → HCID 86742492, 화합물

HRID 868507노트

반응식

HRID 868507 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[O:6][CH2:7][CH2:8]Cl)([O-:3])=[O:2].[NH2:14][CH2:15][CH2:16][C:17]([N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[S:23][CH2:22][CH:21]=[CH:20]1)=[O:18].[C:30](=[O:33])([O-:32])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[O:6][CH2:7][CH2:8][NH:14][CH2:15][CH2:16][C:17]([N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[S:23][CH2:22][CH2:21][CH2:20]1)=[O:18])([O-:3])=[O:2].[C:5]([O-:18])(=[O:6])/[CH:10]=[CH:11]/[C:30]([O-:32])=[O:33]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 43624871-(2-chloroethoxy)-2-nitrobenzeneHCID 21287188HCID 21287188, 화합물

생성물 1

HCID 86742492HCID 86742492, 화합물수율 55.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2-Nitrophenoxyethylchloride (0.26 g), 5-(3-Amino-propionyl)-1,5-benzothiazepine (0.355 g) and potassium carbonate (0.210 g) in toluene (15 ml) was refluxed for 16 hours. After cooling, objective compound (0.184 g) was obtained according to the method of experimental 1. m.p. 178°-180° C.

후처리

  1. temperaturewas refluxed for 16 hours
  2. temperatureAfter cooling

출처 및 근거

ORD 기록
ord-45b8551da0944f52ba6ba44b007c0cc5
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780462

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