Sodium Iodide → 8-[3-[4-(2-Pyrimidinyl)-1-piperazinyl]propyloxy]-8-azaspiro-[4.5]decan-7,9-dione hydrochloride hemihydrate

HRID 868551노트

반응식

HRID 868551 반응식
Br[CH2:2][CH2:3][CH2:4][O:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[ClH:18].Cl.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[OH2:5].[ClH:18].[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:28][CH2:27]1.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:28][CH2:27]1.[ClH:18]

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 142805838-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione

생성물 1

HCID 1317157338-[3-[4-(2-Pyrimidinyl)-1-piperazinyl]propyloxy]-8-azaspiro-[4.5]decan-7,9-dione hydrochloride hemihydrate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g) and 1-(2-pyrimidinyl)piperazine dihydrochloride (3.13 g) in 100 ml of dry CH3CN were added K2CO3 (52.9 mmol) and NaI (200 mg). The mixture was heated to 80° with stirring under N2.

후처리

  1. temperatureThe mixture was heated to 80°

출처 및 근거

ORD 기록
ord-ae8aeebdd77643778ad1bce741e6ff75
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780466

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