Isatin → 1-[2-(N-isopropylbenzylamino)ethyl]isatin

HRID 868576

반응식

HRID 868576 반응식
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].[CH:12]([N:15]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:16][CH2:17]Cl)([CH3:14])[CH3:13]>>[CH:12]([N:15]([CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[CH2:16][CH2:17][N:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3])([CH3:13])[CH3:14]

참가 물질

3

반응물 2

HCID 7054IsatinHCID 48358N-benzyl-N-(2-chloroethyl)propan-2-amine

생성물 1

HCID 543673991-[2-(N-isopropylbenzylamino)ethyl]isatin

실험 절차

By using isatin and the 2-(N-isopropylbenzylamino)ethyl chloride, a method analogous to that described in Reference Example 7 was carried out, and the reaction product was purified with silica gel column chromatography (eluent: chloroform) to obtain 1-[2-(N-isopropylbenzylamino)ethyl]isatin in an oil (yield: 43.4%).

후처리

  1. customthe reaction product was purified with silica gel column chromatography (eluent: chloroform)

출처 및 근거

ORD 기록
ord-76f01a9d89844f46acebacb597d71f37
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780477

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