Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Divinylbenzene-styrene → HCID 86742494, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Divinylbenzene-styrene | HCID 174664 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2-piperidinecarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride | HCID 86742495 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 86742494 | HCID 86742494 | 88.2% |
반응 단계
A solution of DL-2-piperidinecarbonyl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride (2.1 g) in 50 ml water was neutralized with sodium bicarbonate and passed through a column (50 ml) packed with an adsorption resin of styrene/divinylbenzene type (Mitsubishi Chemical Industries, Ltd., "Adsorption Resin SP-207"). After washing the column with 200 ml water, the adsorbed portion was eluted with 200 ml of water/methanol (50/50 by volume), and the solvents were removed by distillation, affording 1.7 g of white powder M.p.: 225°-227° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04780528 |
| 출처 데이터셋 | uspto-grants-1988_10 |
| ORD ID | ord-f4353958bfc6441a9daad1b8df273e8a |
| 출처 메모 | uspto-grants-1988_10 |