alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

HRID 868655노트

반응식

HRID 868655 반응식
Cl.[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:18])[OH:17])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]>O>[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:17])[OH:18])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]

참가 물질

3

반응물 1

HCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

생성물 1

HCID 86742497alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester수율 85.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1.8 g α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in 50 ml water was allowed to pass through a column (50 ml) packed with a weakly basic anion-exchange resin (Dow Chemical Co., "IRA-68"), and the resin was washed with 100 ml water. The washings were added to the effluent, and the combined solution was concentrated under reduced pressure, giving 1.4 g of white powder. M.p.: 168°-170° C.

후처리

  1. washthe resin was washed with 100 ml water
  2. additionThe washings were added to the effluent, and the combined solution
  3. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e239165540134d59bfa22ec56a6f3d39
출처 데이터셋
uspto-grants-1988_10
특허 번호
US04780528

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