Methyl 3-aminopyridine-4-carboxylate → 3-(1,2-Benzoxazol-3-ylamino]pyridine-4-carboxylic acid

HRID 868846

반응식

HRID 868846 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH2:10])=[N:2]1.N[C:12]1[CH:21]=[N:20][CH:19]=[CH:18][C:13]=1[C:14]([O:16]C)=[O:15]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:18]2[CH:19]=[N:20][CH:21]=[CH:12][C:13]=2[C:14]([OH:16])=[O:15])=[N:2]1

참가 물질

3

반응물 2

HCID 1488824Methyl 3-aminopyridine-4-carboxylateHCID 27797491,2-Benzoxazol-3-amine

생성물 1

HCID 762820453-(1,2-Benzoxazol-3-ylamino]pyridine-4-carboxylic acid수율 2%

실험 절차

The title compound was prepared in 2% yield from 1,2-benzoxazol-3-amine and methyl 3-aminoisonicotinate according to the procedure for Preparation 1C, followed by hydrolysis according to Example 1. 1H NMR (400 MHz, DMSO-d6): δ 7.49 (1H, s), 7.73-7.90 (4H, m), 8.38 (1H, s), 9.62 (1H, s), 11.32 (1H, br s). [M+H] calc'd for C13H9N3O3, 256; found 256.

후처리

  1. customfollowed by hydrolysis

출처 및 근거

ORD 기록
ord-997d9fd9926540cca393fe895e243c20
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969343B2

연결된 노트

불러오는 중…