참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methylbenzoxazole | HCID 7225 | — |
| 반응물 | Dimethylacetamide | HCID 31374 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 14972993 | HCID 14972993 | 51.7% |
반응 단계
A mixture of 2-methylbenzo[d]oxazole (3 g, 22.6 mmol) in DMF (3.2 g) and dimethyl acetamide (3.5 g, 29.3 mmol) was stirred under N2 at 145° C. overnight. Then the solution was poured into ice-water and extracted with EtOAc (100 mL×2). The organic phase was washed, dried and concentrated. The residue was purified by column chromatography to get the title compound (2.2 g). MS (ESI) m/z 134 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08969349B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-8751eac5577644d588bc9396371a866f |
|---|
| 출처 메모 | uspto-grants-2015_03 |
|---|
