(3-Phenyl-5-isoxazolyl)methanol → 3-Phenyl-1,2-oxazole-5-carbaldehyde

HRID 868924

반응식

HRID 868924 반응식
[C:1]1([C:7]2[CH:11]=[C:10]([CH2:12][OH:13])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[C:1]1([C:7]2[CH:11]=[C:10]([CH:12]=[O:13])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 2763417(3-Phenyl-5-isoxazolyl)methanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 113672673-Phenyl-1,2-oxazole-5-carbaldehyde수율 67.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (3-phenylisoxazol-5-yl)methanol (0.9 g, 5.1 mmol) in DCM (10 mL) was added pyridinium chlorochromate (PCC) (2.1 g, 10.2 mmol) and the mixture was stirred at room temperature for 2 hours. The reaction was quenched with water, extracted with EtOAc and dried over anhydrous sodium sulfate. The solution was then concentrated under vacuum to give 3-phenylisoxazole-5-carbaldehyde as a light yellow solid (600 mg).

후처리

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationThe solution was then concentrated under vacuum

출처 및 근거

ORD 기록
ord-3f01702367b44dc4b6811f1ac489c814
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969349B2

연결된 노트

불러오는 중…