Ethanol → Ethyl 3-Aminoisonicotinate

HRID 868957

반응식

HRID 868957 반응식
[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]

참가 물질

5

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 4595313-Aminoisonicotinic acid

생성물 1

HCID 2736365Ethyl 3-Aminoisonicotinate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To an ice-cold suspension of 3-aminoisonicotinic acid (8 g, 58 mmol) in ethanol (36 mL) and toluene (36 mL) was added concentrated sulfuric acid (6.4 mL), and the mixture was stirred for 24 h. The solvents were removed under reduced pressure, the residue was dissolved in water, and the solution was adjusted to pH 8 with concentrated ammonium hydroxide to give ethyl 3-aminoisonicotinate (6.5 g). MS (ESI): m/z 167 [M+H]+.

후처리

  1. customThe solvents were removed under reduced pressure
  2. dissolutionthe residue was dissolved in water

출처 및 근거

ORD 기록
ord-5af5714a24524f9b806dd5e0a82c303d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969349B2

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