Ethanol → Ethyl 3-Aminoisonicotinate
반응식
[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]참가 물질
5
실험 절차
To an ice-cold suspension of 3-aminoisonicotinic acid (8 g, 58 mmol) in ethanol (36 mL) and toluene (36 mL) was added concentrated sulfuric acid (6.4 mL), and the mixture was stirred for 24 h. The solvents were removed under reduced pressure, the residue was dissolved in water, and the solution was adjusted to pH 8 with concentrated ammonium hydroxide to give ethyl 3-aminoisonicotinate (6.5 g). MS (ESI): m/z 167 [M+H]+.
후처리
- customThe solvents were removed under reduced pressure
- dissolutionthe residue was dissolved in water
출처 및 근거
- ORD 기록
- ord-5af5714a24524f9b806dd5e0a82c303d
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969349B2
반응 노트
불러오는 중…