Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-8-nitroquinoline → 2-Methyl-8-nitroquinolin-7-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-8-nitroquinoline | HCID 13433 | — |
| 반응물 | Hydrazinium, 1,1,1-trimethyl-, iodide (1:1) | HCID 18683 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2-Methyl-8-nitroquinolin-7-amine | HCID 70097281 | 14.8% |
반응 단계
To a solution of 2-methyl-8-nitroquinoline (1.88 g, 10 mmol) and 1,1,1-trimethylhydrazinium iodide (3.03 g, 15 mmol) in anhydrous dimethyl sulfoxide (20 mL) was added potassium tert-butoxide as a solid (3.36 g, 30 mmol). The mixture was stirred at room temperature for 1 h. The mixture was then poured into saturated aqueous ammonium chloride, and extracted with EtOAc. The organic layer was concentrated and purified by column chromatography to give 2-methyl-8-nitroquinolin-7-amine as a yellow solid (300 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969349B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-05e1fa67160244eb83cd940eecb11d1f |
| 출처 메모 | uspto-grants-2015_03 |