Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium bisulfate → benzyl N-[3-(2-aminoethyl)pyrrolidine-1-carboximidoyl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium bisulfate | HCID 516920 | — |
| 반응물 | tert-butyl N-[2-(pyrrolidin-3-yl)ethyl]carbamate | HCID 21955469 | — |
| 반응물 | Benzyl [amino(methylsulfanyl)methylene]carbamate | HCID 140362141 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | benzyl N-[3-(2-aminoethyl)pyrrolidine-1-carboximidoyl]carbamate | HCID 140379083 | 67.5% |
반응 단계
2.18 g (0.0102 mole) (3RS)-3-(N-tert-butyloxycarbonylaminoethyl) pyrrolidine and 2.81 g (0.0125 mole) N-benzyloxycarbonyl-S-methylisothiourea was dissolved in 30 ml toluene and heated to 60°-70° C. for eight hours followed by stirring at room temperature for one day. 0.3M KHSO4 -solution was added and the water layer was washed with a mixture of the toluene and ethyl acetate and left for 2 days under which time the Boc group was removed. The acidic water phase was made alkaline and extracted four times with CH2 Cl2. The combined organic layer was dried (Na2SO4), filtered and evaporated to yield 2.0 g (51%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723444 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-d42f48a7d3fc473aba6c5139093935b5 |
| 출처 메모 | uspto-grants-1998_03 |