Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 2-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole | HCID 21983559 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline | HCID 21983568 | — |
반응 단계
The title compound is prepared from 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 1,2,3,4-tetrahydroisoquinoline and acetonitrile essentially as described above in example 48 except that the crude product is dissolve in DCM and purified by using a step gradient of 50% ethyl acetate in heptane, to 100% ethyl acetate. Purity by LC/MS (APCI)=96%, [M+H]+=391.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091199B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-f77827b82f184b44a8fecc9f72a1fa72 |
| 출처 메모 | uspto-grants-2006_08 |