Ethanol → 3-Methoxy-4-(1-methylpiperidin-4-yl)aniline
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:16]C(=O)OCC2C=CC=CC=2)[CH:6]=[CH:7][C:8]=1[CH:9]1[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]1.C(O)C>[Pd].C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[CH:9]1[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]1)[NH2:16]참가 물질
5
실험 절차
To a mixture of benzyl [3-methoxy-4-(1-methylpiperidin-4-yl)phenyl]carbamate (Preparation Example 464) (1.26 g), ethanol (20 mL) and THF (10 mL), 5% palladium on carbon (0.38 g) was added and stirred overnight at room temperature under a hydrogen atmosphere at normal pressure. After filtration through celite, the filtrate was distilled off under reduced pressure to give 3-methoxy-4-(1-methylpiperidin-4-yl)aniline (0.80 g) as a light pink solid.
후처리
- additionwas added
- filtrationAfter filtration through celite
- distillationthe filtrate was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-15f27d3dfc67400ca67ec4d94ed292ce
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969336B2
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