1,4-Dioxane → HCID 178488262, 화합물

HRID 869392노트

반응식

HRID 869392 반응식
[Cl:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:24][CH3:25].O1CCOCC1>O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([CH:21]([CH3:23])[CH3:22])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Cl:1])=[C:3]([O:24][CH3:25])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

참가 물질

4

반응물 2

HCID 312751,4-DioxaneHCID 86722240HCID 86722240, 화합물

생성물 1

HCID 178488262HCID 178488262, 화합물수율 85.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10B (10.3 g, 27.33 mmol, crude) and FeCl3.6H2O (33.04 g, 164.0 mmol, 6 eq) was added to 1,4-dioxane (300 mL) The mixture was refluxed for 16 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (300 mL), extracted with ethyl acetate and concentrated to give a crude product 10C (8.75 g), which was used for the next step directly.

후처리

  1. temperaturewas refluxed for 16 hours
  2. customthe reaction
  3. extractionextracted with ethyl acetate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c6d8994519104d73b8fc119851e8f142
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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