Lithium borohydride → HCID 21914755, 화합물

HRID 869396노트

반응식

HRID 869396 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[S:9][CH:10]=1)=O)C.[Li+].[BH4-]>C1COCC1>[C:12]([NH:11][C:8]1[S:9][CH:10]=[C:6]([CH2:4][OH:3])[N:7]=1)(=[O:16])[CH:13]([CH3:15])[CH3:14]

참가 물질

4

반응물 2

HCID 4148881Lithium borohydrideHCID 21914754HCID 21914754, 화합물

생성물 1

HCID 21914755HCID 21914755, 화합물수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

11B (0.73 g, 3 mmol) was dissolved in THF (14 mL). To the solution was added LiBH4 (0.23 g, 10 mmol) in batches at room temperature. The reaction mixture was refluxed overnight, then quenched with 14 mL of anhydrous MeOH and concentrated to dryness. The residue was dissolved in dichloromethane and filtered. The filtrate was concentrated and dried to give a crude product 11C (0.48 g, 100% yield).

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. customquenched with 14 mL of anhydrous MeOH
  3. concentrationconcentrated to dryness
  4. dissolutionThe residue was dissolved in dichloromethane
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated
  7. customdried

출처 및 근거

ORD 기록
ord-9fc6cc235f2d4b5d9850ea158d98f2e9
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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