HCID 21914755, 화합물 → HCID 21914786, 화합물

HRID 869397노트

반응식

HRID 869397 반응식
[C:1]([NH:6][C:7]1[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3]>C1COCC1.O=[Mn]=O>[CH:12]([C:10]1[N:11]=[C:7]([NH:6][C:1](=[O:5])[CH:2]([CH3:3])[CH3:4])[S:8][CH:9]=1)=[O:13]

참가 물질

4

반응물 1

HCID 21914755HCID 21914755, 화합물

생성물 1

HCID 21914786HCID 21914786, 화합물수율 50.4%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

11C (0.5 g, 2.5 mmol) was dissolved in THF (10 mL). To the solution at room temperature was added activated MnO2 (1.74 g, 20 mmol). The reaction mixture was refluxed overnight, then filtered. The filtrate was concentrated and dried to give a crude product 11D (0.25 g, 50% yield).

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customdried

출처 및 근거

ORD 기록
ord-9f604a989b0f492380e5dab8441b0aab
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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