HCID 86722244, 화합물 → HCID 178488264, 화합물

HRID 869400노트

반응식

HRID 869400 반응식
[Cl:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:27][CH3:28]>C1COCC1.O=[Mn]=O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Cl:1])=[C:3]([O:27][CH3:28])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

참가 물질

4

반응물 1

HCID 86722244HCID 86722244, 화합물

생성물 1

HCID 178488264HCID 178488264, 화합물수율 60.3%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

11F (500 mg, 1.19 mmol) was dissolved in THF (tetrahydrofuran, 30 mL). To the solution was added activated MnO2 (600 mg, 6 eq, 6.9 mmol). The mixture was refluxed for 48 hours. After reaction completed, the mixture was cooled and filtered. The cake was washed well with THF and MeOH. The filtrate was concentrated and purified by column chromatography on silica gel to give 300 mg of pure product (11G).

후처리

  1. temperatureThe mixture was refluxed for 48 hours
  2. customAfter reaction
  3. temperaturethe mixture was cooled
  4. filtrationfiltered
  5. washThe cake was washed well with THF and MeOH
  6. concentrationThe filtrate was concentrated
  7. custompurified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-04f9cea192bf4e1eb39e89784a8d9ef5
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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