HCID 86722263, 화합물 → HCID 178488263, 화합물

HRID 869418노트

반응식

HRID 869418 반응식
[Br:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:27][CH3:28]>C1COCC1.O=[Mn]=O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Br:1])=[C:3]([O:27][CH3:28])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

참가 물질

4

반응물 1

HCID 86722263HCID 86722263, 화합물

생성물 1

HCID 178488263HCID 178488263, 화합물수율 65.8%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
110 °C

실험 절차

A mixture of 16B (1.1 g, 2.3 mmol) and MnO2 (6 g) in THF (20 mL) was heated to 110° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was filtered and the filtrate was concentrated to give 16C (0.7 g, 63.9% yield).

후처리

  1. customreacted overnight
  2. customthe reaction
  3. filtrationthe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5528cf74dfc54dfeac025641fb32599e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969373B2

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