Acetic Acid → HCID 178476732, 화합물

HRID 869450노트

반응식

HRID 869450 반응식
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[N+:6]([O-])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:12]([OH:15])(=[O:14])[CH3:13]>N1C=CC=CC=1.[Fe]>[C:12]([OH:15])(=[O:14])[CH3:13].[N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4]([OH:14])=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 3392321-Oxo-1lambda~5~-1,5-naphthyridine

생성물 1

HCID 178476732HCID 178476732, 화합물

시약·촉매·용매 2

HCID 23925Iron촉매HCID 1049Pyridine용매

실험 절차

To a solution of 1,5-naphthyridin-5-oxide 4-01 (D-5) (330 mg, 2.0 mmol, 1.0 eq) in acetic acid (12 mL) and pyridine (2.5 mL) at RT, iron powder (456 mg, 8.15 mmol, 4.0 eq) is added in portions (over 10 min) and the resulting mixture is stirred for 2 h. The mixture is filtered and the solid is rinsed with acetic acid. The filtrate is concentrated in vacuo. The residue is triturated with acetone and then filtered. The filter cake is rinsed with acetone and dried in vacuo to afford the product, 1,5-naphthyridin-4-ol acetic acid salt (D-6).

후처리

  1. filtrationThe mixture is filtered
  2. washthe solid is rinsed with acetic acid
  3. concentrationThe filtrate is concentrated in vacuo
  4. customThe residue is triturated with acetone
  5. filtrationfiltered
  6. washThe filter cake is rinsed with acetone
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-d92b4189a0ae44c4877aabd49bd8f0f2
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969363B2

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