Aluminium lithium hydride → HCID 71744071, 화합물

HRID 869477노트

반응식

HRID 869477 반응식
[N:1]1[CH:2]=[C:3]([C:10](OCC)=[O:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[N:1]1[CH:2]=[C:3]([CH2:10][OH:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 71744070Ethyl imidazo[1,2-B]pyridazine-3-carboxylate

생성물 1

HCID 71744071HCID 71744071, 화합물수율 57%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of ethyl imidazo[1,2-b]pyridazine-3-carboxylate (1.91 g, 10 mmol) in anhydrous THF (20 mL), lithium aluminium hydride (1.34 g, 35 mmol) was added in portions over 15 min. After stirring at RT for 16 h, the mixture was quenched with ice-water (20 mL) and then extracted with ethyl acetate (30 mL×2). The combined organic layers were washed with brine, dried over Na2SO4 then filtered. The filtrate was concentrated in vacuo to afford imidazo[1,2-b]pyridazin-3-ylmethanol (0.85 g, 57% yield).

후처리

  1. customthe mixture was quenched with ice-water (20 mL)
  2. extractionextracted with ethyl acetate (30 mL×2)
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationthen filtered
  6. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-4afacf5250e445019a0d7611ee1548d6
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969363B2

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