Triacetoxyperiodinane → Imidazo[1,2-b]pyridazine-3-carbaldehyde

HRID 869478노트

반응식

HRID 869478 반응식
[N:1]1[CH:2]=[C:3]([CH2:10][OH:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[N:1]1[CH:2]=[C:3]([CH:10]=[O:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 71744071HCID 71744071, 화합물

생성물 1

HCID 45083595Imidazo[1,2-b]pyridazine-3-carbaldehyde수율 90.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of imidazo[1,2-b]pyridazin-3-ylmethanol (45 mg, 0.3 mmol) and Dess-Martin periodinane (130 mg, 0.3 mmol) in anhydrous DCM (5 mL) were stirred at RT overnight. The reaction mixture was quenched with water (5 mL). The organic layer was separated, dried over MgSO4 and filtered. The filtrate was concentrated in vacuo to afford imidazo[1,2-b]pyridazine-3-carbaldehyde (40 mg, 90.7% yield).

후처리

  1. customThe reaction mixture was quenched with water (5 mL)
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-4cf7c16a8cc64a238b23a4b4c272371b
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969363B2

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