Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-cyclopropyl-1H-1,3-benzodiazole → (E)-2-{8-[(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-cyclopropyl-1H-1,3-benzodiazole | HCID 1084419 | — |
| 반응물 | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| 생성물 | (E)-2-{8-[(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile | HCID 86721335 | 96.3% |
반응 단계
Using 2-cyclopropyl-1H-benzo[d]imidazole (Europeane Journal of Organic Chemistry, 2000, p 1229, 69 mg, 0.434 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (160 mg, 0.447 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (182 mg, 95%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969345B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-5adbb5e158554deb9cb74299d2350cb2 |
| 출처 메모 | uspto-grants-2015_03 |