2-(2'-Pyridyl)benzimidazole → (E)-2-(3-fluoro-8-{[2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

HRID 869517

반응식

HRID 869517 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[NH:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[N:8]=1.Br[CH2:17][C:18]1[CH:37]=[CH:36][C:21]2/[C:22](=[C:32](/[CH3:35])\[C:33]#[N:34])/[C:23]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:24]=3[O:25][CH2:26][C:20]=2[CH:19]=1>>[F:31][C:28]1[CH:29]=[CH:30][C:23]2=[C:24]([CH:27]=1)[O:25][CH2:26][C:20]1[CH:19]=[C:18]([CH2:17][N:11]3[C:10]4[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=4[N:8]=[C:7]3[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[CH:37]=[CH:36][C:21]=1/[C:22]/2=[C:32](/[CH3:35])\[C:33]#[N:34]

참가 물질

3

반응물 2

HCID 708212-(2'-Pyridyl)benzimidazoleHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

생성물 1

HCID 86721346(E)-2-(3-fluoro-8-{[2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile수율 86%

실험 절차

Using commercially available 2-(pyridin-2-yl)-1H-benzo[d]imidazole (50 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.335 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (123 mg, 86%) was obtained.

후처리

  1. customobtained in Reference Example 1

출처 및 근거

ORD 기록
ord-c2075802c5634941aff09722a869a1cf
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969345B2

연결된 노트

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