Ammonia → 2-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide

HRID 869535

반응식

HRID 869535 반응식
[CH3:1][S:2][C:3]1[C:4]([N+:10]([O-:12])=[O:11])=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].N1C=CC=CC=1.[CH3:19][O:20][CH2:21][C:22](Cl)=[O:23].N>CC(N(C)C)=O.O.CO>[CH3:19][O:20][CH2:21][C:22]([NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([S:2][CH3:1])[C:4]=1[N+:10]([O-:12])=[O:11])=[O:23]

참가 물질

8

반응물 4

HCID 222AmmoniaHCID 1049PyridineHCID 96623Methoxyacetyl chlorideHCID 109761553-(Methylthio)-2-nitroaniline

생성물 1

HCID 867213652-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide수율 91%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 31374Dimethylacetamide용매

실험 절차

[step 2] 3-(Methylthio)-2-nitroaniline (1.0 g, 5.4 mmol) obtained in step 1 was dissolved in DMA (5.4 mL), pyridine (0.44 mL, 5.4 mmol) and 2-methoxyacetyl chloride (1.49 mL, 16 mmol) were added, and the mixture was stirred at room temperature for 2 hr. To the reaction solution were added methanol and aqueous ammonia, and the mixture was stirred at room temperature for 30 min. Water was added, and the crystals were collected by filtration, and dried to give 2-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide (1.26 g, 91%).

후처리

  1. stirringthe mixture was stirred at room temperature for 30 min
  2. filtrationthe crystals were collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-2cc65d3a3b3a4620afaf63eea3ce3d7a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969345B2

연결된 노트

불러오는 중…