Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(azetidin-1-yl)-1H-benzo[d]imidazole → (E)-2-(8-{[2-(azetidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(azetidin-1-yl)-1H-benzo[d]imidazole | HCID 59605883 | — |
| 반응물 | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| 생성물 | (E)-2-(8-{[2-(azetidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile | HCID 86721383 | 59% |
반응 단계
[step 2] Using 2-(azetidin-1-yl)-1H-benzo[d]imidazole (40 mg, 0.23 mmol) obtained in step 1 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (84 mg, 0.24 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (61 mg, 59%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969345B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-e9fe6462aa9c4ba2a6e88065de5c1d9a |
| 출처 메모 | uspto-grants-2015_03 |