Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole → (E)-2-(3-fluoro-8-{[2-(pyrrolidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole | HCID 6991896 | — |
| 반응물 | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| 생성물 | (E)-2-(3-fluoro-8-{[2-(pyrrolidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile | HCID 86721384 | 91% |
반응 단계
Using commercially available 2-(pyrrolidin-1-yl)-1H-benzo[d]imidazole (63 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.34 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (141 mg, 91%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969345B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-01b709a5206641059ab6bcd00ad1c223 |
| 출처 메모 | uspto-grants-2015_03 |