Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propyl-1H-benzimidazole → (E)-2-{3,4-difluoro-8-[(2-propyl-1H-benzo[d]imidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propyl-1H-benzimidazole | HCID 21624 | — |
| 반응물 | (E)-2-[8-(bromomethyl)-3,4-difluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721398 | — |
| 생성물 | (E)-2-{3,4-difluoro-8-[(2-propyl-1H-benzo[d]imidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile | HCID 86721397 | 90% |
반응 단계
Using 2-propyl-1H-benzo[d]imidazole (Synthetic Communication, 2002, vol. 32, p 3703; 17 mg, 0.10 mmol) and (E)-2-[8-(bromomethyl)-3,4-difluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (40 mg, 0.12 mmol) obtained in Reference Example 4, and in the same manner as in Reference Example 1A, the title compound (41 mg, 87%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969345B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-704a7aa2cf7448438ec79cb43a033d07 |
| 출처 메모 | uspto-grants-2015_03 |