HCID 178470236, 화합물 → HCID 178524884, 화합물

반응식

[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH:12]2COC2C(C(OCC)=O)=NC=CC=2)=[O:10])[CH2:5][CH2:4]1.CO[C:33]1[CH:34]=[C:35]([O:44][CH2:45][C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)[C:36]([C:39]([O:41]CC)=[O:40])=[N:37][CH:38]=1>>[F:30][C:2]([F:1])([F:29])[C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([N:11]2[CH2:12][CH2:13][CH:14]([CH2:45][O:44][C:35]3[C:36]([C:39]([OH:41])=[O:40])=[N:37][CH:38]=[CH:33][CH:34]=3)[CH2:15]2)=[O:10])[CH2:7][CH2:8]1

참가 물질

반응물 2

HCID 178470236HCID 178470236, 화합물

HCID 178470258HCID 178470258, 화합물

생성물 1

HCID 178524884HCID 178524884, 화합물

실험 절차

The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 31 using ethyl 3-((1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-3-yl)methoxy)picolinate (EXAMPLE 92 Step 3) in stead of ethyl 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinate.

출처 및 근거

ORD 기록: ord-a2519661683c4849bd4779711f6c7b66
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08969383B2

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