1-(2,3-Dihydro-1H-inden-5-yl)ethan-1-one → 2,3-dihydro-1H-indene-5-carboxylic acid

HRID 869852

반응식

HRID 869852 반응식
Cl[O-].[Na+].[CH2:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13](=[O:15])C)[CH:11]=2)[CH2:6][CH2:5]1.C([O-])(O)=[O:17].[Na+]>>[CH2:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([OH:15])=[O:17])=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

참가 물질

4

반응물 3

HCID 2339761-(2,3-Dihydro-1H-inden-5-yl)ethan-1-oneHCID 516892Sodium BicarbonateHCID 23665760Sodium Hypochlorite

생성물 1

HCID 2328412,3-dihydro-1H-indene-5-carboxylic acid수율 99%

실험 절차

To a stirred aqueous sodium hypochlorite solution (2230 ml, 1.80 mmol, 6□) at 55□ was added 1-(2,3-dihydro-1H-inden-6-yl)ethanone (120.0 g, 0.75 mol) and the mixture was stirred at 55□ for 2 h. After cooling to room temperature, saturated NaHCO3 solution was added until the solution became clear. The produced precipitate was filtered, washed several times with water and dried to afford the desired product (120.0 g, 99%). 1H NMR (CDCl3, 300 MHz) δ 2.07-2.17 (m, 2H), 2.96 (t, J=7.5 Hz, 4H), 7.30 (d, J=7.8, 1H,), 7.91 (d, J=7.8, 1H), 7.96 (s, 1H).

후처리

  1. filtrationThe produced precipitate was filtered
  2. washwashed several times with water
  3. customdried

출처 및 근거

ORD 기록
ord-b55a6a3c2a5a49118e82c2685b28bfbe
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969386B2

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