Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | HCID 178418772 | HCID 178418772 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine | HCID 15870142 | 97% |
반응 단계
13.8 kg of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine and 11.5 kg of phosphorus oxychloride were refluxed in acetonitrile, and stirred for 4 hours. The reaction solution was combined with water, and the precipitated crystal was separated, and the resultant crystal was washed and dried to obtain 14.6 kg of the target compound as a pale yellow crystal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091206B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-566f636694d74e4bbcaca894597ef315 |
| 출처 메모 | uspto-grants-2006_08 |