Triethylamine → 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-n-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide

To a solution of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)cyclopropanecarboxylic acid (44.04 mg, 0.2 mmol) in dichloromethane (2 mL) was added thionyl chloride (14.6 μL, 0.20 mmol) followed by DMF (1 drop) and the reaction was stirred at room temperature for 30 minutes. The solvent was removed by rotovap. Toluene (˜1 mL) was added and mixed with the residue and then removed by rotovap. The toluene step was repeated once more and then the residue was placed under high vacuum for 10 minutes. It was then dissolved in dichloromethane (1 mL) and a solution of 6′-methoxy-3,5′-dimethyl-2,3′-bipyridin-6-amine (46 mg, 0.20 mmol) and triethylamine (83.6 μL, 0.60 mmol) in dichloromethane (1 mL) was added. The reaction was stirred at room temperature for 12 hours. The reaction was then concentrated. The residue was dissolved in DMSO and purified by reverse phase HPLC (10-99% CH3CN in water) to yield 16 mg of the product. ESI-MS m/z calc. 431.2. found 432.5 (M+1)+. Retention time 1.98 minutes.

1. customThe solvent was removed by rotovap
2. additionToluene (˜1 mL) was added
3. additionmixed with the residue
4. customremoved by rotovap
5. waitthe residue was placed under high vacuum for 10 minutes
6. dissolutionIt was then dissolved in dichloromethane (1 mL)
7. stirringThe reaction was stirred at room temperature for 12 hours
8. concentrationThe reaction was then concentrated
9. dissolutionThe residue was dissolved in DMSO
10. custompurified by reverse phase HPLC (10-99% CH3CN in water)

ORD 기록

ord-050bddf62f07418088240756d1dd83b4

출처 데이터셋

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08969386B2