Chlorosuccinimide → (2-Bromo-5-chlorothiophen-3-yl)methanol

HRID 870029노트

반응식

HRID 870029 반응식
[Br:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[CH2:7][OH:8].[Cl:9]N1C(=O)CCC1=O>C1COCC1.O>[Br:1][C:2]1[S:3][C:4]([Cl:9])=[CH:5][C:6]=1[CH2:7][OH:8]

참가 물질

5

반응물 2

HCID 31398ChlorosuccinimideHCID 12479010(2-Bromothiophen-3-yl)methanol

생성물 1

HCID 57900970(2-Bromo-5-chlorothiophen-3-yl)methanol

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-bromo-3-hydroxymethylthiophene from Example 1, Step 1 (13.0 g, 67.3 mmol) in THF (100 mL) and water (10 mL) was added N-chlorosuccinimide (9.88 g, 74.0 mmol) and the mixture was stirred at r.t. for 5 h and concentrated in vacuo. The residue was worked up as above to afford the desired product. The crude product was used directly.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-127fbcdd4fee4fa897c12acf1cd519ff
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969394B2

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