Diethyl (benzylamino)methylphosphonate → Diethyl (aminomethyl)phosphonate

HRID 870136노트

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HRID 870136 반응식
C([NH:8][CH2:9][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])C1C=CC=CC=1>C(O)C.C(O)(=O)C.[C].[Pd]>[NH2:8][CH2:9][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]

참가 물질

5

반응물 1

HCID 10923173Diethyl (benzylamino)methylphosphonate

생성물 1

HCID 1596920Diethyl (aminomethyl)phosphonate

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 176Acetic Acid용매HCID 702Ethanol용매

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온도
50 °C

실험 절차

A 250-mL pressure tank reactor was purged, flushed and maintained with a hydrogen atmosphere, then, was added a solution of diethyl (benzylamino)methylphosphonate (3.5 g, 13.62 mmol, 1.00 equiv) in ethanol (180 mL), acetic acid (10 mL) and Palladium carbon (0.2 g, 0.10 equiv). The resulting solution was stirred for 24 h at 50° C. under 20 atm pressure. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 2.0 g (crude) of the title compound as brown oil which was used without further purification.

후처리

  1. customA 250-mL pressure tank reactor was purged
  2. customflushed
  3. temperaturemaintained with a hydrogen atmosphere
  4. filtrationThe solids were filtered out
  5. concentrationThe resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-ee3306a6d62b48dc884c95f95a73112f
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969377B2

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