Diethyl (aminomethyl)phosphonate → (3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)methylphosphonic acid
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([NH:23]CCP(=O)(O)O)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1.N[CH2:31][P:32](=[O:39])([O:36]CC)[O:33]CC>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([NH:23][CH2:31][P:32](=[O:33])([OH:39])[OH:36])(=[O:21])=[O:22])[CH:17]=[CH:18][CH:19]=1참가 물질
3
실험 절차
Compound 5 was prepared in an analogous manner to that of Compound 1 using diethyl aminomethylphosphonate (Intermediate 5.3) as the amine. 1H-NMR (300 MHz, CD3OD, ppm): 7.89 (d, J=7.8 Hz, 1H), 7.74 (s, 1H), 7.63˜7.66 (m, 1H), 7.57˜7.61 (m, 2H), 6.97 (s, 1H), 4.80˜4.89 (m, 1H), 4.55˜4.67 (m, 2H), 3.83˜3.89 (m, 1H), 3.55˜3.66 (m, 1H), 3.02˜3.11 (m, 5H). MS (ES, m/z): 465 [M+H]+.
출처 및 근거
- ORD 기록
- ord-ff5f58fe59ca4a619ca799d6731ceea1
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969377B2
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