Lipoic acid → 5-(1,2-Dithiolan-3-YL)pentanoyl chloride

HRID 870284

반응식

HRID 870284 반응식
S(Cl)([Cl:3])=O.[CH2:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)[S:8][S:7][CH2:6]1>C(Cl)Cl>[S:7]1[CH2:6][CH2:5][CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([Cl:3])=[O:16])[S:8]1

참가 물질

4

반응물 2

HCID 6112Lipoic acidHCID 24386Thionyl Chloride

생성물 1

HCID 579942155-(1,2-Dithiolan-3-YL)pentanoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of thionyl chloride (1.4 mL, 7.5 mmol) in CH2Cl2 (30 ml) at 0° C. was added a solution of lipoic acid (3.0 g, 5 mmol), dissolved in dichloromethane, dropwise over 1 h. The mixture was allowed to stir for additional 3 h. at the same temperature. After completion of the reaction the solvent was removed under vacuum using a dry-ice collection trap being very careful not to heat the reaction mixture since this will decompose the product. Reaction proceeds with quantitative yield.

후처리

  1. customAfter completion of the reaction the solvent
  2. customwas removed under vacuum
  3. customa dry-ice collection trap
  4. temperatureto heat the reaction mixture since
  5. customReaction

출처 및 근거

ORD 기록
ord-7db339e89ef343b4a22a7d0cf2e8d423
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969549B2

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